The Chemo-Toxicity Calculator is a pre-chemotherapy assessment that captures sociodemographics, tumor/treatment variables, laboratory test results (hemoglobin, creatinine clearance), and geriatric assessment variables (function, comorbidity, cognition, psychological state, social activity/support, and nutritional status). The Chemo-Toxicity Calculator is based on the results of a study which enrolled 500 patients across seven participating institutions, in order to identify factors that predict risk of severe chemotherapy-related side effects in older adults with cancer (Hurria et al. JCO 2011). The results from this study were identified by the American Society of Clinical Oncology’s as one of the Clinical Cancer Advances in 2012. Having this predictive model that incorporates geriatric and oncologic correlates of vulnerability to chemotherapy toxicity in older adults could help both the healthcare provider and the patient weigh the benefits and risks of chemotherapy treatment. Our ultimate goal is to utilize this Chemo-Toxicity Calculator in clinical practice, where it can be used as a part of shared decision-making.
The Chemo-Toxicity Calculator is also available in Spanish, Japanese, Chinese, Korean, Armenian, Farsi, Arabic, Tagalog, Vietnamese, and Portuguese. Production of the translated versions on the website is ongoing. For more information, please complete the Contact Us inquiry form here.
A geriatric assessment is utilized to capture information about a patient’s medical history as well as functional, cognitive, and psychosocial status, which can then be used by treating physicians to identify the most vulnerable patients (for example, those at high risk for chemotherapy toxicity). However, these assessments have not been routinely used in oncology practice because of the time and resources required for their administration. A geriatric assessment tool (that can be completed primarily by patients) was developed for incorporation into oncology clinical trials and routine care settings.1,2 The domains that are assessed include functional status, comorbidities, medications, nutritional status, cognitive function, and psychosocial status.
Please click on the below for more information regarding the geriatric assessment tool:
1Hurria et al. Cancer 2005
2Hurria et al. JCO 2011
The Geriatric Assessment is available in Spanish, Mandarin, Japanese, Korean, Armenian, Farsi, Arabic, Tagalog, Vietnamese, and French. Production of the translated versions on the website is ongoing. For more information, please complete the Contact Us inquiry form here.