CARinG Pilot Grants

The Cancer and Aging Research Group (CARG) Infrastructure Grant is requesting applications for two pilot projects in the field of cancer and aging research. The goal is for this pilot funding to provide support for investigator pilot projects that can lead to externally funded awards.

Applications must include plans/strategies for how the study will:
1) Address an issue concerning cancer and aging
2) Support research teams focused on cancer and aging research
3) Lead to publications and extramural funding

Deadline for submission: TBA

NIH/NIA R21/R33 CARinG Pilot Grants

  • Nine awards will be funded during the grant period
  • The goal is for this internal pilot funding to serve as a foundation/model upon which future investigators will design and initiate research projects leading to externally funded awards and foster research collaborations across cancer centers.
  • Each application must be accompanied by a letter of support from the institution of the investigator, and must discuss explicitly how CARG infrastructure resources (e.g. data, Core support) are needed to facilitate the next steps for the research

Pilot Grant 1

Title: Development of a Personalized Discussion Priorization Tool for Older Adults Considering Adjuvant Chemotherapy for Breast Cancer
Co-PIs: Allison Magnuson, DO and Mina Sedrak, MD, MS

Grant Period: September 1. 2019 – August 31, 2020

Overall Objective: Develop and test a technology-mediated DPT, which integrates personalized information on risk factors for adjuvant chemotherapy-related toxicity in older women with breast cancer
Specific Aims
Aim 1: Conduct a secondary analysis of patients enrolled on NCT01472094 to determine the association between clinical factors and reduced RDI of a prescribed chemotherapy regimen.
Aim 2: Adapt a DPT to include personalized information regarding risk of chemotherapy toxicity and risk of reduced RDI, and evaluate the usability of the DPT in ten older adults considering adjuvant chemotherapy for breast cancer.

Pilot Grant 2

Title: Evaluation of Loneliness and Social Isolation in Older Adults with Cancer
PI: Katherine Clifton, MD

Grant Period: March 2021 – February 2022*

Overall Objective: Develop an intervention to combat loneliness and social isolation in older adults with cancer using stakeholder input and feedback from patient advocates.

Specific Aims
Aim 1: Assess loneliness and social isolation during the COVID-19 pandemic in older adults with cancer.
Aim 2: Adapt an intervention to address loneliness in older adults with cancer during the COVID-19 pandemic for the future.

Pilot Grant 3

Title: A Telehealth Advance Care Planning Intervention for Older Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome
PI: Melissa Loh, BMedSci, MBBCh, BAO

Grant Period: March 2021 – February 2022*

Overall Objective: Adapt and assess the feasibility and usability of a telehealth-delivered ACP intervention for older patients with AML and MDS. The optimization of the ACP intervention will be guided by the Center for eHealth and Wellbeing Research (CeHRes) Roadmap which emphasizes structural stakeholder involvement.
Specific Aims
Aim 1: To incorporate telehealth into an evidence-based ACP intervention that is adapted for older patients suffering from AML and MDS utilizing qualitative interviews with patients, their caregivers, and oncology providers
Aim 2: To assess the feasibility and usability of the adapted telehealth-delivered ACP intervention in a single-arm pilot study of 20 older patients with AML and MDS.

Pilot Grant 4

Title: Geriatric Assessment with Management for Older Adult Hematopoietic Cell Transplant Candidates
PI: Sarah Wall, MD, MPH

Grant Period: March 2021 – February 2022*

Specific Aims
Aim 1: Determine the relationship between geriatric assessment with management (GAM) and post-transplant outcomes in a historical cohort of older adult allogeneic hematopoietic cell transplant (allo-HCT) recipients
Aim 2: Evaluate the effectiveness of GAM to optimize physical function, nutrition, mental health, and medication adherence in a prospective pilot study of adults ≥ 60 years old undergoing evaluation for allo-HCT

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