Program announcements that may be related to cancer and aging research


Notice of NCI's Participation on PA-17-226, Advancing the Science of Geriatric Palliative Care (R21)
https://grants.nih.gov/grants/guide/notice-files/NOT-CA-17-055.html

Advancing the Science of Geriatric Palliative Care (R01)
https://grants.nih.gov/grants/guide/pa-files/PA-18-502.html

Advancing the Science of Geriatric Palliative Care (R21)
https://grants.nih.gov/grants/guide/pa-files/PA-18-503.html

Self-Management for Health in Chronic Conditions (R01)
https://grants.nih.gov/grants/guide/pa-files/PA-18-376.html

Conference Grants to Advance Collaborative Research on Aging Biology (R13)
https://grants.nih.gov/grants/guide/pa-files/PAR-15-265.html

Partnership for Aging and Cancer Research (U01 Clinical Trial Not Allowed)
https://grants.nih.gov/grants/guide/pa-files/PAR-18-552.html

Samuel Waxman Cancer Research Foundation (SWCRF) Research collaborations in Aging and Cancer
The goal of the SWCRF Research Collaborations in Aging and Cancer program is to encourage, support, and facilitate collaboration among NCI and NIA intramural investigators (those conducting research within the labs and clinics of the NCI or NIA) and extramural NCI or NIA grantees (those conducting research in labs outside the NIH) through the initiation of novel interdisciplinary research projects, sharing resources and reagents, and developing novel technologies and approaches needed to address the role of aging in cancer.

Scientific/Research Contacts
  1. Felipe Sierra, PhD, Division of Aging Biology/NIA, 301-496-6402, sierra@mail.nih.gov
  2. Ron Kohanski, PhD, Division of Aging Biology, 301-496-6402, kohanskir@mail.nih.gov

Collaborators
  1. Chamelli Jhappan, Ph.D., Cancer Immunology, Hematology & Etiology Branch, National Cancer Institute, 240-276-6220, jhappenc@dc37a.nci.nih.gov
  2. Thomas A. Mistelli, Ph.D., Center for Cancer Research, National Cancer Institute, 301-496-4345, mistellit@mail.nih.gov
  3. Luigi Ferrucci. M.D., Ph.D., Office of the Scientific Director, National Institute on Aging, 410-558-8110, ferruccilu@grc.nia.nih.gov

Immunity and the Elderly
Older individuals exhibit an increased susceptibility to infectious diseases, with increased respiratory and/or cardiovascular complications and prolonged hospitalization.
Knowledge gaps still exist in understanding mechanisms behind poor vaccine efficacy and responses to infection in the elderly.
There also is a growing interest in determining connections between immune status and healthy aging versus chronic inflammation, known as "inflammaging." More human studies are needed to elucidate these interactions and this FOA will support basic studies related to defining mechanisms of dysfunction in the aged innate and adaptive immune systems in response to infectious pathogens or vaccines.

Scientific/Research Contacts
  1. Rebecca Fuldner, Ph.D., Division of Aging Biology, National Institute on Aging, 301-402-6402, fuldnerr@nia.nih.gov

Evolving Implementations for Training Cognition in Aging
In 2010, the NIA first commissioned a systematic review by the Agency for Healthcare Research and Quality (AHRQ) that generated a state-of-the-science report on the prevention of cognitive decline and dementia. That review concluded that there was insufficient evidence to make recommendations about any intervention strategy for either outcome.
Given the recommendations for future research and the current situation as outlined above, the proposed initiative consists of an RFA soliciting one or possibly two planning awards to develop and finalize protocols for well-powered cognitive training intervention trials to remediate or prevent age-related cognitive decline, as well as possibly prevent or delay the onset of dementia. Trial designs would need to include state-of-the-art outcome measures, including behavioral and biological markers, and perform pre-, post-, and maintenance structural and functional imaging.
Scientific/Research Contacts
  1. Jonathan W. King, Ph.D., Division of Behavioral and Social Research, National Institute on Aging, 301-402-4156, kingjo@nia.nih.gov
  2. Molly V. Wagster, Ph.D., Division of Neuroscience, National Institute on Aging, 301-496-9350, wagsterm@nia.nih.gov

Collaboratory on Research Definitions for Cognitive Resilience and Reserve
Although chronological age itself remains the strongest predictor of age-related cognitive decline, mild cognitive impairment (MCI), and many forms of dementia including Alzheimer’s disease (AD) and Alzheimer’s disease-related dementias (ADRD), there appear to be protective factors against some or all of these outcomes whose mechanisms of protection are poorly understood, and which in some cases are replicated only inconsistently.
Given the growth in the worldwide burden of AD and the continued failure of clinical trials, the focus of the possibility for intervention at ever earlier disease stages or for primary prevention in middle age or earlier has sharpened.

Scientific/Research Contacts
  1. Molly V. Wagster, Ph.D., Division of Neuroscience, National Institute on Aging, 301-496-9350, wagsterm@nia.nih.gov
  2. Jonathan W. King, Ph.D., Division of Behavioral and Social Research, National Institute on Aging, 301-402-4156, kingjo@nia.nih.gov

Dementia Care and Caregiver Support Interventions
Laying the groundwork for pragmatic trials in dementia care can be accomplished by directly supporting early-stage behavioral intervention development clinical trials aimed at adapting/modifying interventions for the real world, examining the principles underlying these interventions, developing methods to ensure fidelity of delivery, and developing training procedures for community interventions.
This initiative is intended to replace the clinical trials portion of PAR-15-348, "Research on Informal and Formal Caregiving for Alzheimer's Disease (R01)."

Scientific/Research Contacts
  1. Lisa Onken, Ph.D., Division of Behavioral and Social Research, National Institute on Aging, 301-402-4156, lisa.onken@nih.gov

Sleep disorders and circadian clock disruption in Alzheimer’s disease and other dementias of aging
Difficulties with sleep are common complaints among the elderly, with up to 50 percent or more older Americans reporting chronic sleep problems.
There are several grants currently funded by NIA which encompass sleep, the circadian clock, and Alzheimer’s disease. However, this portfolio is skewed toward research examining associations between disturbed sleep and cognitive decline, as well as imaging and cerebrospinal fluid biomarkers of Alzheimer’s disease; these are patient-oriented, and predominantly cross-sectional studies on existing cohorts.
As of July 2017, there were just two R01-type grants focused on the molecular and/or cellular mechanisms of sleep/circadian rhythms in AD.

Scientific/Research Contacts
  1. Miroslaw (Mack) Mackiewicz, Ph.D., Division of Neuroscience, National Institute on Aging, 301-496-9350, miroslaw.mackiewicz@nih.gov

Sensory and motor system changes as predictors of preclinical Alzheimer’s disease
There are, however, some data to suggest that assessment of multiple sensory and/or motor modalities in conjunction with other molecular, genetic, or imaging biomarkers may improve the diagnostic accuracy of preclinical AD but more research is needed. Further investigation is also needed to disentangle the sensory and motor changes associated with AD from those associated with normal aging to harness their potential as early, noninvasive AD biomarkers.
This initiative will fill a gap area that is not being sufficiently addressed by other NIA AD initiatives and follows on the heels of a recent report from the National Academies of Sciences, Engineering, and Medicine recommending methodological improvements to clinical trials aimed at preventing cognitive decline and dementia. These recommendations include initiating interventions at younger ages and allowing for longer follow-up periods. Identifying noninvasive biomarkers of preclinical AD would be crucial to improving AD prevention trials.

Scientific/Research Contacts
  1. Coryse St. Hillaire-Clarke, Ph.D., Division of Neuroscience, National Institute on Aging, 301-496-9350, sthillaireclacn@mail.nih.gov

Consequences of amyloid protein polymorphisms in AD
The goal of this RFA is to identify molecular and cellular mechanisms underlying the formation of these protein conformers in AD and the potential of these variations in disease pathology and transmission. This FOA will also encourage both unbiased and hypothesis-driven approaches to characterize the regulation of biochemical and cellular process that are responsible for time course, clinical presentation, and neuropathological accumulation of these amyloid polymorphs.
Scientific/Research Contacts
  1. Austin Yang, Ph.D., Division of Neuroscience, National Institute on Aging, 301-496-9350, austin.yang@nih.gov

Job opportunities related to cancer and aging research


  1. Georgetown is conducting a national search for several positions in aging research as part of a new initiative. There are opportunities for researchers across several aging-related fields, clinical researchers, and post-docs. There are also opportunities for leadership for more senior candidates. More information can be found here.
  2. The University of Rochester School of Medicine, Division of Geriatrics & Aging is conducting a national search for an Associate Chief for Research to build a robust interdisciplinary program of study that spans the Division and links it to related centers of academic excellence across the University. More information can be found here.
  3. Moffitt’s Senior Adult Oncology Program is expanding! We received approval to hire a junior clinical investigator at the Assistant Professor level. We put together a really nice package to help you flourish as a budding clinical researcher. If you are at the end of your fellowship or already in your Assistant Professorship (some credit for years can be given), and are passionate about geriatric oncology research, send us your CV! Details in the flyer attached. Or go online at HealthcareSource Job Search.
  4. Research Faculty Position in the Division of Geriatrics at the University of California, San Diego:

    We seek an MD and/or PhD to conduct aging research. Multiple opportunities for collaborative research will be available. The division wishes to increase the number of faculty who conduct research in a broad array of aging-focused topic areas. Candidates must have an MD, MD/PhD, or PhD and ability to make original and significant contributions to a research program.
    The candidate must have an active and innovative research program. The successful candidates will be expected to 1) demonstrate and maintain a high quality, extramurally-funded research program, 2) maintain professional competence by participating in our clinical programs (if a clinician), 3) demonstrate excellence in the teaching of medical and/or graduate students, 4) provide service to the University and academic community at a level commensurate with his/her career stage, and 5) contribute to the maintenance of a collegial and collaborative academic environment.

    Clinician applicants must have a Certificate of Added Qualification in Geriatrics or similar certification for other clinical disciplines and must be eligible for a California medical license or other pertinent clinical license.

    The Department is interested in candidates who have demonstrated commitment to excellence by providing leadership in teaching, research or service towards building an equitable and diverse scholarly environment.

    Appointment will be at the Assistant, Associate or Full Professor rank. Series will be determined by the successful candidate’s skills and qualifications. Salary is commensurate with qualifications and based on University of California pay scales.

    Applications must be submitted through the University of California San Diego’s Academic Personnel RECRUIT system at: https://apol-recruit.ucsd.edu/apply/JPF01373.

    If you are interested in this position please provide your CV and a statement of interest and send to:

    Alison A. Moore, MD, MPH, FACP, AGSF
    Larry L. Hillblom Chair in Geriatric Medicine
    Chief, Division of Geriatrics
    Departments of Medicine and Psychiatry
    University of California, San Diego
    9500 Gilman Drive, MC 0665
    San Diego, CA 92093
    PH: 858-246-2449 (direct line)
    Fax: 858-822-6151
    alisonmoore@ucsd.edu
    http://geriatrics.ucsd.edu
  5. The American Cancer Society is seeking a candidate with 20+ years of experience to lead the American Cancer Society’s Behavioral Research Center (BRC) in Atlanta, GA. This is a Vice President position reporting to our Chief Medical Officer, Dr. Otis Brawley, who will lead a group of 5 PhD level scientists and 4 Master’s level scientists.

    The BRC conducts behavioral/social research on cancer prevention, screening, and survivorship--the current portfolio focuses on smoking cessation, quality of life, aging, health equity and online intervention development, implementation, and dissemination. More information can be found at: https://jobs.cancer.org/job/atlanta/vp-behavioral-research-center/79/4856885.